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  • Reviews for Richard Conniff’s Books

    Every Creeping Thing: True Tales of Faintly Repulsive Wildlife: “Conniff is a splendid writer–fresh, clear, uncondescending, and with never a false step; one can’t resist quoting him.” (NY Times Book Review)

    The Species Seekers:  Heroes, Fools, and the Mad Pursuit of Life on Earth by Richard Conniff is “a swashbuckling romp” that “brilliantly evokes that just-before Darwin era” (BBC Focus) and “an enduring story bursting at the seams with intriguing, fantastical and disturbing anecdotes” (New Scientist). “This beautifully written book has the verve of an adventure story” (Wall St. Journal)

    Swimming with Piranhas at Feeding Time by Richard Conniff  is “Hilariously informative…This book will remind you why you always wanted to be a naturalist.” (Outside magazine) “Field naturalist Conniff’s animal adventures … are so amusing and full color that they burst right off the page …  a quick and intensely pleasurable read.” (Seed magazine) “Conniff’s poetic accounts of giraffes drifting past like sail boats, and his feeble attempts to educate Vervet monkeys on the wonders of tissue paper will leave your heart and sides aching.  An excellent read.” (BBC Focus magazine)

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Posts Tagged ‘cholera’

A Probiotic Vaccine Aims to Stop Cholera Epidemics Fast

Posted by Richard Conniff on June 20, 2018

by Richard Conniff/Scientific American

The most terrifying things about cholera is its lethal speed. A victim can consume contaminated food or water, come down with diarrhea a day later and, if untreated, be dead a day after that—having inadvertently spread the microorganism to friends, neighbors and family members in the meantime. Hence cholera’s reputation for tearing explosively through populations, mostly recently in Haiti beginning in 2010 and Yemen in 2016.

Two major challenges—one diagnostic, the other preventive—make it difficult to stop cholera epidemics: A simple field test can distinguish cholera from other forms of diarrhea, but only after symptoms have already appeared. And although existing vaccines can prevent the disease, they require two or three weeks to elicit protective immunity. Neither diagnosis nor vaccination is fast enough for public health workers racing to stop the first few cases of cholera from breaking out into an epidemic.

Two new studies published this month in Science Translational Medicine could change that, although both are still in preliminary testing on animal models of cholera. In the first study researchers at Massachusetts Institute of Technology wanted to know “whether we could engineer a bacterium that could serve both to diagnose and prevent cholera,” says senior author James Collins. The researchers focused on Lactococcus lactis, which people have routinely consumed for thousands of years in cultured dairy products like yogurt and sour cream.

The initial plan for treatment was to genetically engineer the bacterium “to produce and secrete antimicrobial peptides specific to cholera,” Collins says. But on attempting to culture L. lactis in a laboratory dish together with the cholera pathogen, he says, the researchers found to their “pleasant surprise” that no such engineering was needed: L. lactis “was either inhibiting or killing off the cholera” on its own. This was apparently because the lactic acid it secretes creates an inhospitable environment for the cholera pathogen in the petri dish—as it also presumably does in the small intestine. In testing on laboratory mice 84.6 percent of those fed L. lactis and the cholera pathogen together survived, compared with 45.7 percent of those fed the cholera pathogen alone. When the researchers experimentally altered L. lactis to stop it from producing lactic acid, this protective effect disappeared. It was, Collins says, the first time anyone has demonstrated Read the rest of this entry »

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